Black-and-gold flat millipede possesses a defense mechanism that releases cyanide compounds as a deterrent to predators. While toxic, the substances do not seep out and generally pose a threat only upon ingestion. Human encounters with this toxin are considered to have mostly mild effects, causing irritation or discomfort rather than severe or long-term health issues.

Black-and-gold flat millipede naturally produces defense enzymes that release a toxic substance as a means of deterring potential predators. These chemicals can cause discomfort if handled improperly or accidentally ingested by humans, resulting in a range of mild irritations. Close human contact with black-and-gold flat millipede is not commonly sought after, but incidental encounters can occur due to the creature's natural habitat overlapping with human living spaces or activities.

To minimize troubles with black-and-gold flat millipede, reduce habitat overlap by maintaining clean living spaces, sealing cracks, and decluttering areas where they may hide. Use physical barriers such as screens or nets to deter their entry. Removing decaying wood and leaf litter near dwellings can also discourage black-and-gold flat millipede from establishing nearby, thus preventing accidental contact.

In the event of an inadvertent interaction with black-and-gold flat millipede, washing the affected area thoroughly with soap and water can help alleviate any discomfort. Ventilate the area to dispel any toxins released. During the recovery period, avoid contact with the species and maintain cleanliness. Ensuring that living and work environments remain unappealing to black-and-gold flat millipede will help avoid repeated issues. Hands should be washed regularly to prevent potential toxin spread, especially before eating or touching the face.