Cat-faced spider possesses a mild venom that it delivers through its fangs. It uses its venom primarily as a defensive measure and to subdue prey. When it bites, the effects differ among various animals. Humans might experience slight discomfort or localized pain, usually with minimal consequences. Household pets like dogs and cats may have a mild reaction, while small mammals such as rodents could be more affected due to their lower body mass. Insects, being smaller, can succumb to the venom, which allows cat-faced spider to feed. The toxicity is most prominent during the adult stage of cat-faced spider.

Cat-faced spider, like many spiders, typically bites humans only in defense. These bites are uncommon and happen when they feel threatened or are accidentally pressed against human skin. Cat-faced spider uses its fangs to bite, but the consequence is usually mild, similar to a bee sting, due to their non-aggressive nature and the venom impact on humans.

Cat-faced spider are generally not aggressive towards humans; however, issues arise when humans inadvertently encroach upon their space, causing them to act defensively. Spiders may bite if they feel pressed against the skin or threatened. While their venom is usually not harmful to humans, reactions similar to bee stings can occur, which, though rare, cause discomfort.

To avoid issues with cat-faced spider, maintain a clean living environment, reducing clutter where they may hide. Regularly inspect and clear out potential nesting sites, including dark corners, under furniture, and in garages or sheds. Sealing entry points around windows and doors also minimizes encounters. Use LED lighting outside, as it attracts fewer insects, which are cat-faced spider's food source.

If trouble with cat-faced spider occurs, the best approach is to gently clean the affected area with soap and water. Apply a cold compress to reduce any swelling and soothe discomfort. To minimize adverse effects, maintain a calm environment as stress may exacerbate symptoms. While recovering from an encounter with cat-faced spider, be vigilant about potential signs of secondary infection and maintain a clean environment to support healing, though such complications are infrequent.