Oval St. Andrew's cross spider possesses a venom that is considered mildly toxic. It secretes venom through its fangs, primarily as an effective means to capture prey and in defense. Among animals, humans might experience mild discomfort and localized symptoms if bitten. Small mammals like rats can suffer from more pronounced reactions, while insects such as bees can be incapacitated or killed outright, serving as prey to oval St. Andrew's cross spider. The toxic effects vary among different animals, with smaller creatures generally more at risk from the spider's bite.

Oval St. Andrew's cross spider does not typically exhibit biting behavior towards humans. These spiders may bite in self-defense if they feel threatened or are directly handled but generally avoid human interaction. Bites, if they occur, are rare and usually result in mild symptoms similar to a bee sting with no severe consequences.

The oval St. Andrew's cross spider tends to avoid humans, and bites are uncommon. Trouble arises if these spiders are provoked or mishandled, leading to self-defensive bites. Because oval St. Andrew's cross spider shares habitats with humans, occasional encounters can occur, especially when their webs are disturbed or during garden activities.

To prevent issues with oval St. Andrew's cross spider, maintain clean and clutter-free outdoor spaces. Use protective gloves when gardening, and regularly manage vegetation to reduce habitats. Shaking out clothing and equipment stored in garages or sheds before use can also minimize encounters.

If bitten, cleaning the area with soap and water is advisable. Applying cold compresses may soothe minor symptoms. To minimize risk, avoid direct contact with oval St. Andrew's cross spider and its web. During recovery, refrain from scratching to prevent secondary infections and monitor the bite for changes. Safe physical barriers like window screens and maintaining distance can also be effective.