Argiope aetheroides poses a mild risk due to its venom, which is typically delivered through a bite. As an adult, argiope aetheroides uses fangs to inject its toxin into both larger animals and smaller organisms. While the effects of the venom can cause discomfort in humans and domestic animals like dogs, it often has a more severe impact on smaller prey such as rodents and insects. The reaction to the venom varies among different species, from mild irritation to more serious symptoms, depending on the size and resilience of the animal involved.

Argiope aetheroides is not known for biting humans as it is not characteristic of this species. These spiders typically bite only in self-defense and their bites are generally harmless to humans, causing only mild reactions owing to their non-aggressive nature.

Argiope aetheroides generally cause trouble to humans accidentally, as they are not aggressive and do not seek out human interaction. Troubles often arise from unintentional encounters such as inadvertently disturbing argiope aetheroides's habitat, resulting in self-defense bites. These species spin webs in areas that may intersect with human activity, sometimes leading to unexpected contact.

To prevent the troubles associated with argiope aetheroides, awareness of their presence is key. Regularly inspect and clean areas such as garages, sheds, and under eaves for webs. When working in areas where argiope aetheroides may be found, wear gloves and be cautious of their potential presence. Keep vegetation around the house trimmed to minimize web-building spots.

If troubles with argiope aetheroides occur, calmly and gently free yourself from the source of trouble. Clean the affected area with soap and water. Apply a cold pack to alleviate any mild discomfort. It is important to keep the site clean and monitor for signs of secondary issues. During recovery, avoid disturbing other potential argiope aetheroides habitats to prevent further mishaps. Seek professional advice should any concerning symptoms arise.