The signature spider typically uses its venom both for prey capture and self-defense. When signature spider bites, their fangs inject a mild venom, which can cause slight discomfort or allergic reactions in humans and domestic animals like dogs and cats. Although the toxicity is considered mild for larger animals, smaller creatures such as birds or lizards may experience more significant effects due to their size and different physiology. The adult stage of the signature spider is when it's capable of envenomation, primarily affecting those animals upon which it preys or that threaten it.

Signature spider typically avoids biting humans. Bites are rare, occurring mainly when individuals feel threatened or are handled roughly. The spider's bite mechanism involves injecting venom through fangs, but for humans, the impact is usually mild, akin to a bee sting, with temporary discomfort.

Signature spider generally avoids interaction with humans, and bites are typically defensive rather than aggressive. However, when their webs are disturbed or if they feel threatened, particularly when being handled, they may bite as a natural self-defense mechanism. These instances are relatively rare though, as signature spider prefers to reside in undisturbed areas.

To prevent unwelcome encounters with signature spider, regular maintenance of homes and gardens is suggested. Clearing away webs and maintaining a clutter-free environment can discourage signature spider from taking up residence. Additionally, being cautious when moving objects where signature spider may hide and wearing protective gloves during gardening can further reduce the likelihood of bites.

After experiencing a bite from signature spider, keeping the area clean and avoiding scratching can minimize discomfort and promote healing. Cold compresses can be applied to soothe the area. It's important to stay calm, as stress can exacerbate symptoms. During recovery, avoiding disturbing other signature spider habitats can prevent further incidents. Keeping surroundings tidy will discourage signature spider from returning to the area.