St. Andrew's cross spider is known to possess a mild level of toxicity that poses certain risks primarily through its bite. By utilizing its fangs, st. Andrew's cross spider can inject venom into its victim, which can cause discomfort and mild symptoms to an array of animals such as humans, birds, lizards, and frogs. While it has the capability to affect both larger and smaller creatures, the impact of the poison tends to be less severe in larger animals due to their size and physiological resistance, whereas smaller animals like insects may experience more significant effects.

St. Andrew's cross spider rarely bites humans, and such incidents are primarily defensive when they are provoked or threatened. These bites typically occur when a human comes into direct contact with st. Andrew's cross spider. The biting method involves using fangs to inject venom, which in most cases results in mild symptoms due to the spider's non-aggressive nature towards humans.

St. Andrew's cross spider, while not typically aggressive to humans, may bite as a defensive response if they feel threatened. This often occurs when a person inadvertently comes into direct contact with them. Such encounters are possible due to st. Andrew's cross spider's habitat, which may overlap with human environments such as gardens, homes, or recreational areas.

To prevent encounters with st. Andrew's cross spider, maintain a clean and tidy environment, reducing clutter where st. Andrew's cross spider may hide. Regularly inspect and clean spots like garages, sheds, and garden areas. Use appropriate protective gear like gloves when moving objects or vegetation where st. Andrew's cross spider might reside.

After an encounter with st. Andrew's cross spider, keeping calm is important. Clean the affected area with soap and water to remove any contaminants. Apply a cold pack to reduce swelling and discomfort. While severe reactions are rare, monitor the situation closely. During recovery, avoid disturbing the affected area and engage in relaxing activities that maintain a stress-free environment for optimal healing.