Lobed argiope typically delivers venom via a bite through its fangs. Its venom is of a mild intensity and can affect various animals, including humans, dogs, cats, birds, and numerous insects. Juvenile and adult stages of this species have the capability to poison other organisms. The outcomes of exposure to the venom can vary between a minor irritation to more severe symptoms. Although it has a broader impact on smaller creatures, large animals may experience discomfort or mild reactions.

Lobed argiope typically does not display biting behavior towards humans. Bites are rare and occur only in defense when they feel threatened. Such defensive bites may happen during unintentional contact with humans. The consequence is usually a mild reaction due to the spider's non-aggressive nature and venom that is not potent for humans.

The troubles caused by lobed argiope mainly arise from accidental interactions, as these arachnids are not naturally aggressive towards humans. In their quest for prey, lobed argiope can inadvertently become a nuisance if they dwell in human habitats, leading to defensive bites when they feel cornered or threatened by unsuspecting humans.

To prevent issues with lobed argiope, keep living areas clean and free from clutter that may serve as hiding spots. Regularly check and clear out corners and less-frequented parts of the home. Utilize window screens and door seals to deter lobed argiope from entering indoor spaces.

If troubles with lobed argiope occur, keeping the affected area clean and avoiding disturbance can help in recovery. Gentle cleaning with soap and water is recommended. To minimize adverse outcomes, employing barriers to separate living spaces from lobed argiope is effective. During the recovery period, it is crucial to remain calm and to avoid areas with a known presence of lobed argiope.