Garden cross spider delivers its venom through fangs, primarily when bitten. Typically, its toxin is mild, and while it might cause discomfort in mammals like humans, dogs, and cats, the impact is generally not severe. Smaller animals, such as birds and insects, may experience more pronounced effects due to the toxic compounds, especially considering their smaller body masses. The venom of garden cross spider is utilized in both defense and predation, tailored to incapacitate smaller prey and deter larger threats.

Garden cross spider does not typically display biting behavior towards humans. Bites from garden cross spider are rare and primarily occur when these spiders feel threatened, often during unintentional contact. The bite typically results in mild symptoms, similar to a bee sting, without severe consequences for most individuals.

Garden cross spider generally avoids human interaction but may bite if they feel threatened, such as when accidentally touched or pressed. Their presence in human habitats increases the likelihood of such unintended contact, potentially leading to bites that cause discomfort similar to a bee sting, primarily due to the spider's defensive mechanism.

Preventative measures against garden cross spider include maintaining a clean and clutter-free environment to deter them from settling. Regularly removing webs and employing natural repellents such as eucalyptus oil or citrus scents can discourage garden cross spider from occupying human spaces. Additionally, wearing gloves while gardening can prevent accidental encounters.

If issues arise from an interaction with garden cross spider, it's beneficial to remain calm and clean the area gently with soap and water. Applying a cold compress can help reduce any swelling or discomfort. It's important to avoid scratching the site to prevent infection. During recovery, keeping the affected limb elevated and monitoring the area for changes ensures proper healing without aggravating the condition.