Banded argiope typically applies its mild venom through a bite using its fangs. Adult banded argiopes possess the ability to poison animals that they encounter or use it defensively. When humans or dogs are bitten, they might experience minor discomfort and localized reactions. However, reactions can vary among animals; for example, smaller creatures like flies may succumb to the venom, while frogs might show greater resilience, suffering little more than irritation.

Banded argiope rarely bite humans and only do so in self-defense when feeling threatened. Such instances are infrequent, largely due to their avoidance of human contact. Bites occur when provoked during handling or accidental contact and produce mild, localized symptoms without severe consequences.

Banded argiope's typically avoid humans and bite only when they feel threatened or are provoked. Humans may encounter these creatures in their natural habitats, such as gardens or wooded areas. When humans inadvertently disturb banded argiope, especially by handling them or making accidental contact, banded argiope may bite as a defensive measure.

To prevent unwanted encounters with banded argiope, it is advisable to exercise caution when working in areas where they may live, such as gardens or near webs. Wearing gloves and long sleeves can serve as a barrier against accidental contact. Regularly clearing away webs from around the home can also minimize the presence of banded argiope.

If a person has had an unfortunate encounter with banded argiope, it is important to keep the affected area clean and to observe for signs of infection. Applying cold compresses can help reduce any swelling or discomfort. Individuals should avoid scratching the site to prevent secondary infections. During recovery, it is crucial to maintain good hygiene and to monitor the area for changes. While significant symptoms are rare, seeking advice from health professionals may be prudent if there are concerns.