Grey House Spider typically uses its fangs to deliver a mild venom to deter predators and capture prey. The toxin can cause discomfort in humans and small mammals such as mice upon biting, but it is rarely dangerous. However, insects might suffer more severe consequences due to their smaller size and different physiology, including paralysis or death. Both juvenile and adult stages of grey House Spider possess the capacity to envenomate, utilizing this defense and predatory mechanism throughout their life span.

Grey House Spider typically does not bite humans. If disturbed or threatened, grey House Spider might defensively bite as a last resort. Such incidents are uncommon and largely happen accidentally, with the bites being mild and rarely leading to significant consequences for humans.

Grey House Spider, by nature, are not aggressive towards humans and generally avoid contact. They may only bite if they feel trapped or are accidentally disturbed, such as when a person puts on a shoe without noticing the grey House Spider inside or when they handle an grey House Spider unintentionally. Bites are typically a defense mechanism rather than an offensive action.

To prevent unwanted encounters with grey House Spider, maintain cleanliness at home and reduce clutter where grey House Spider might seek refuge. Regularly vacuum to remove any grey House Spider or webs. Seal cracks and crevices in walls and around windows to deter grey House Spider from entering. Also, shake out clothing and shoes before use.

After an accidental bite by grey House Spider, keeping the affected area clean and dry is crucial to avoid infection. Apply a cold compress to reduce swelling and soothe irritation. Monitor for signs of a secondary infection and seek medical advice if the area becomes excessively red, swollen, or painful. It's important to rest and avoid aggravating the affected area while it heals. Be sure to use only safe, non-medicated methods for symptom relief.