Carrhotus xanthogramma typically employs its venom for predation and defense. This arachnid administers venom through its fangs when it bites, a method effective against various animals. Humans may experience mild discomfort upon being bitten, with symptoms often limited to localized pain or itching. Smaller mammals such as dogs and cats might exhibit more pronounced reactions, though generally non-lethal. Furthermore, carrhotus xanthogramma may incapacitate or deter other arthropods, such as insects, ensuring its survival. The adult stage is notably the period when carrhotus xanthogramma is toxic.

Carrhotus xanthogramma does not typically engage in biting humans. In the rare event of a bite, it would likely be a defensive action when feeling threatened. Biting is not a habitual method for interacting with humans, and bites are usually harmless with only mild consequences.

Carrhotus xanthogramma rarely interacts with humans in a harmful way. Troubles arise primarily from accidental encounters that may lead to defensive actions, such as when a person startles or threatens carrhotus xanthogramma. These instances are unusual, as carrhotus xanthogramma does not seek out human interaction and generally prefers to avoid larger animals.

To prevent any problems with carrhotus xanthogramma, it is advisable to avoid their habitats and to be mindful of their presence. Regular cleaning and removal of clutter can reduce hiding spots for carrhotus xanthogramma. Installing fine mesh screens on windows can prevent them from entering homes, reducing the likelihood of encounters.

In the off chance that a person faces trouble from carrhotus xanthogramma, maintaining calm and distancing oneself from the creature is crucial. Afterwards, cleaning the area with soap and water is a simple measure to keep the site clean. People should be reminded to remain observant of their recovery and seek professional advice if needed while avoiding disturbing the area of trouble.