Tailed cellar spider typically harms other animals through biting with its fangs, often resulting in a mild toxic reaction. The adults are responsible for this action. For example, when humans or dogs accidentally come into contact with tailed cellar spider, they may experience discomfort or minor symptoms due to the mild toxicity. Smaller pests, such as houseflies and beetles, can also be affected, potentially leading to more significant distress or even fatality due to their smaller size and different physiological responses to the toxin.

Typically, tailed cellar spider does not exhibit human-biting behavior. Their method of predation is not suited for human skin penetration, and they show no aggression towards humans. Encounters leading to bites are rare, accidental, and often defensive. Consequences of such unintended bites are minimal, causing only mild and localized discomfort.

Tailed cellar spider rarely cause trouble for humans as they usually do not bite. However, when they do, it's often because their habitats overlap with human living spaces, leading to accidental encounters. Their presence in homes is generally due to their search for prey, which can sometimes inadvertently involve humans, particularly if the tailed cellar spider is disturbed or threatened.

To prevent the unintentional run-ins with tailed cellar spider, ensure homes are well-sealed by checking for cracks or gaps where these creatures might enter. Regular cleaning can also reduce the insects that tailed cellar spider prey on, making the environment less attractive to them. Utilizing screens on windows and keeping vegetation away from the house can also deter their approach.

If you encounter tailed cellar spider, calmly remove them with the assistance of a container and a piece of paper, releasing them outside away from living areas. Should an accidental bite occur, the area should be kept clean and observed for signs of excessive redness or swelling. A cold compress can help to relieve any discomfort. During recovery, avoid scratching the area to minimize the risk of secondary infection.