Trashline orbweaver is known to possess a mild venom, which is utilized as both a defense and hunting mechanism. Though the toxin is mild, when trashline orbweaver bites, it can cause discomfort and allergic reactions in humans and discomfort in domestic animals like dogs and cats. Smaller mammals may experience more pronounced symptoms due to their size. Insects, being smaller and more directly targeted as prey, are efficiently subdued by the venom. Different animals exhibit varying reactions based on their size, physiology, and exposure to the toxin.

Trashline orbweaver is not commonly known to bite humans. Typically, bites may occur if the spider feels threatened, in a defensive posture rather than as predatory behavior. The method involves using their fangs to deliver a bite, which can cause mild reactions due to venom, although they’re generally harmless to humans.

Trashline orbweaver, like many in the Araneidae family, tends to cause unease more due to their appearance and the stigma around spiders than the actual threat they pose. Humans often encounter trashline orbweaver in their living spaces or while interacting with nature. When trashline orbweaver feels cornered or threatened, it may bite defensively, leading to mild discomfort for the person involved.

To prevent issues with trashline orbweaver, regular cleaning can deter them from establishing themselves in living areas. Clearing away debris and sealing cracks can limit their access. In outdoor settings, wearing gloves while gardening and checking clothing before and after spending time in nature can minimize the chances of unintentional encounters with trashline orbweaver.

In the event of experiencing trouble with trashline orbweaver, it's crucial to remain calm and avoid disturbing the spider further. Gently brushing it away should be sufficient. To alleviate any discomfort, cleaning the area with soap and water may help. It's important to keep the affected area elevated and to use a cold pack to reduce swelling. During the recovery, one should ensure that the area is kept clean and monitored for any changes. Remember, bites from trashline orbweaver are typically mild and complications are rare.