Median wasp's defense mechanism involves a potent sting capable of delivering neurotoxins to deter predators. In humans, these neurotoxins can cause pain, swelling, and redness. Severe cases might involve nausea or dizziness, but typically, symptoms are mild and short-lived with no long-term complications.

Median wasp has a specialized method of delivering its mild venom through bites utilizing its fangs. This venom typically causes irritation and discomfort rather than serious harm. Humans, for instance, may experience symptoms such as localized pain or mild allergic reactions. Smaller animals like dogs, cats, birds, and frogs can also be affected, potentially exhibiting more pronounced reactions due to their size and varying sensitivity to the toxins, although the severity remains generally low. The adult stage of median wasp is when the toxicity is most prevalent.

Median wasp typically sting humans in defense of their colony or when they feel threatened. Stinging incidents often result from close human interactions with their nests. The species can sting multiple times, and while not typically aggressive, a sting can cause pain and allergic reactions in humans. Female median wasp are solely responsible for stinging, as males lack stingers. After stinging, there are no physical consequences for the median wasp.

Median wasp stings occur mainly as a form of defense when they feel their colony is threatened or when they are provoked. Because median wasp often establish nests near human habitations, accidental encounters are common, increasing the likelihood of stinging incidents. Additionally, the ability of median wasp to sting repeatedly elevates the risk of multiple stings during such encounters.

To prevent encounters with median wasp, avoid nesting sites and be cautious during activities that may disturb their habitats. Preventative measures include regular inspections of potential nesting sites around homes and removal of unwanted vegetation. Sealing entry points in buildings can also deter median wasp from establishing nests close to human activity.

After a median wasp sting, the immediate step is to gently remove any visible stinger and cleanse the area with soap and water. Applying a cold pack can help reduce pain and swelling. It's advisable to keep the affected limb elevated and remain as still as possible to prevent spreading the venom. Monitor for signs of a more severe reaction and seek medical assistance if necessary. During recovery, avoid scratching the area and maintain cleanliness to prevent secondary infections.