Giant centipede possesses a venomous bite through which it delivers neurotoxins to subdue prey. Though not typically lethal to humans, a bite causes significant pain, swelling, and potential tissue damage. Symptoms are usually mild, but severe cases can involve neurological complications. Caution is advised when handling or near these centipedes.

Giant centipede can pose a threat through skin contact or if ingested by animals and humans. For instance, when a curious pet like a dog or a cat comes into contact with giant centipede, it may experience mild to severe reactions. On the other hand, predatory mammals and birds hunting giant centipede might suffer from the poison's effects through ingestion. Reptiles that come into contact with or consume the larvae or adults of giant centipede could similarly be affected, displaying a range of adverse symptoms resulting from the toxin which is used as a defense mechanism by the organism.

Giant centipede may bite humans usually in self-defense. They employ their powerful mandibles to deliver the bite, which can cause mild to severe discomfort. Biting typically occurs when giant centipede feels threatened, making human interaction potentially risky. Immediate effects include pain, swelling, and in some cases, systemic reactions requiring medical attention.

Giant centipede can cause discomfort to humans primarily due to their self-defense mechanism. When they feel threatened, they may bite, deploying neurotoxic venom. Given their habitat often intersects with human dwellings and their nocturnal activity, accidental encounters with humans can result in bites, leading to pain, swelling, and other symptoms.

To prevent troubles from giant centipede, ensure homes are sealed from potential entry points. Use natural deterrents such as boric acid around perimeters. Regular cleaning helps to eliminate the small insects and arthropods that giant centipede prey on, thereby reducing their incentive to enter human habitats. Additionally, exercise caution when moving objects under which giant centipede may hide.

If trouble with giant centipede occurs, cleaning the area with soap and water is a first step to minimize the chances of infection. Using cold compresses can help reduce pain and swelling. It's important to rest and keep the affected limb elevated. Implementing physical barriers and maintaining a clean environment can help prevent future occurrences. During recovery, avoid unnecessary strain to the affected area to promote healing.