Southwestern trapdoor spider has a mild level of toxicity that is typically delivered through biting with its fangs. While the venom can affect various animals, the intensity of the reaction varies. Humans, along with pets such as dogs and cats, might experience mild discomfort, swelling or pain at the site of the bite. The severity is often low in these larger animals, causing minimal harm. Smaller creatures like insects can suffer more due to the relative potency of venom in their smaller bodies; however, it rarely causes any fatal outcomes.

Southwestern trapdoor spider typically do not exhibit biting behavior towards humans, as such incidents are not characteristic of this species. If bites occur, they are generally mild and are a result of defense mechanisms when threatened rather than aggressive tendencies.

Southwestern trapdoor spider's interactions with humans are uncommon as they are not prone to biting. However, troubles may arise if humans inadvertently encroach on their habitat or handle them carelessly, prompting a defensive response. In such scenarios, a bite may occur, albeit rarely, and typically results in mild discomfort.

To prevent any issues with southwestern trapdoor spider, be cautious in areas where they may live, such as undisturbed soils or under rocks. Use protective gloves when gardening or moving debris. Seal cracks and crevices in homes to deter them from entering, and regularly clear out clutter where they may hide.

If experiencing discomfort from an southwestern trapdoor spider defensive action, keep the affected area clean and use a cool compress to alleviate any mild symptoms. Refrain from scratching to avoid secondary infections. During the recovery period, monitor the situation, and maintain good hygiene. Seek professional advice if symptoms persist or worsen, ensuring a safe response to any reactions.