Humpbacked orbweaver typically utilizes its fangs to inject a mild venom into its prey, which includes smaller mammals and certain domesticated animals such as dogs and cats. The toxic effects can range from minor irritation to more significant discomfort, depending on the size and resilience of the animal. While humans may experience some discomfort upon being bitten, the venom is generally not harmful to them. Juvenile and adult stages of humpbacked orbweaver are capable of envenomation, although the reactions to their venom can vary among different animal species.

Humpbacked orbweaver is not known for biting humans habitually. As a spider species, if they encounter humans, biting is generally a defensive action in response to a perceived threat. Their mandibles might deliver a mild bite out of self-protection, but this is quite rare and typically has minor consequences.

The spider species humpbacked orbweaver typically does not pose a habitual threat to humans. However, interactions with humans can occur, often if the spider feels threatened or disturbed in its environment. Instances of humpbacked orbweaver causing trouble are primarily defensive in nature, a response to protect itself when in close contact with humans. Since bites are rare, the level of concern remains minimal for most individuals.

To avoid any issues with humpbacked orbweaver, it is advisable to maintain a clean environment, reducing clutter where spiders may nest. Regularly inspecting and cleaning corners, basements, and less-disturbed areas can discourage humpbacked orbweaver from settling in. Sealing cracks and openings in one's home also limits access points for humpbacked orbweaver and contributes to prevention efforts.

In the event of an interaction with humpbacked orbweaver that causes discomfort, it's important to keep the affected area clean and to reduce initial inflammation by applying a cold compress. Refraining from scratching helps to prevent secondary infections. Consultation with a healthcare provider is recommended if symptoms persist or worsen. During recovery, ensure the area is kept clean and avoid disturbing other potential humpbacked orbweaver habitats.