When spinybacked Orbweaver employs its fangs to bite, the venom, although typically mild in toxicity, can affect certain animals. For example, humans may experience minor irritation and discomfort, while dogs might show similar mild reactions. Insects, however, can be more significantly harmed or even killed, as the venom is particularly efficient against smaller organisms. The adult stage of spinybacked Orbweaver is capable of envenomation, and it uses this defense mechanism against predators and for prey capture.

Spinybacked Orbweaver is not characteristic of biting humans. Encounters with humans generally do not result in bites, as spinybacked Orbweaver employs biting primarily for prey capture and defense against natural predators, not humans. Bites, if they occur, are likely accidental and resulting effects are minor and localized.

Spinybacked Orbweaver seldom causes direct harm to humans as it typically avoids contact. However, its web placement in human-inhabited areas may lead to accidental encounters. Since these creatures use their venom primarily for subduing prey, any inadvertent trouble caused to humans is usually due to defensive behavior or unintentional contact with the web.

To prevent accidental run-ins with spinybacked Orbweaver, habitual clearing of cobwebs from around the home and garden is advisable. Installing screens on windows can minimize their indoor intrusion. Periodic inspection and cleaning of less frequented spaces can also deter them from establishing their webs in human living areas.

In the rare event of an encounter with spinybacked Orbweaver resulting in discomfort, it's advisable to remain calm and clean the area with soap and water to prevent infection. Utilizing cold compresses can help soothe any mild irritation. As these instances are seldom severe, the focus should be on keeping the affected area clean while avoiding scratching to facilitate unhindered recovery. It's important to maintain a clean environment to minimize further contact during this period.