Black-and-white spiny spider typically uses its sting to subdue its prey for survival. The mild venom it secretes may affect a variety of arthropods including insects and spiders. For many of these creatures, the sting may be paralyzing or lethal. Despite its primary role in predation, the venom's low toxicity is unlikely to cause severe harm to larger animals, and its effects on creatures outside its usual prey spectrum are minimal. Adult black-and-white spiny spiders are the ones that possess the ability to sting and deliver venom, as this is when they are actively hunting and require the venom most.

Black-and-white spiny spider is not known for typically biting humans; occurrences are rare. If bites happen, they're defensive, not aggressive, and follow human provocation. Bites by adult black-and-white spiny spider are mild without severe consequences. Such behavior aligns with typical black-and-white spiny spider's instinct for survival rather than predation on humans.

Black-and-white spiny spider rarely cause direct harm to humans as they do not typically seek out human interaction. Trouble with black-and-white spiny spider may arise when humans unintentionally provoke them, leading to a rare defensive bite. The inclination for this species to bite is rooted in self-preservation rather than aggression towards or preying on humans.

To prevent unwelcome encounters with black-and-white spiny spider, maintain a clean environment with reduced clutter that can act as potential shelters. Regularly check and clear out secluded spots in homes and gardens. Use screens on windows and doors to prevent black-and-white spiny spider from entering living spaces, and be cautious when handling firewood or debris.

In the rare event of a black-and-white spiny spider bite, first remain calm and gently clean the area with soap and water. Apply a cold compress to reduce any swelling and monitor the bite for signs of infection. While recovering, keep the affected area elevated if possible, and avoid scratching to prevent secondary infection. Remember, the symptoms are typically mild and should resolve without severe consequences.