Long-winged kite spider typically uses its fangs to inject venom into prey or as a defense. The venom is mild and often results in minimal effects on larger animals like humans and dogs; however, smaller mammals may experience more pronounced discomfort. The toxin attacks the nervous system, and while it can subdue small prey, it's rarely a serious threat to larger animals. Only the adult stage of long-winged kite spider exhibits this toxic trait.

Long-winged kite spider is not known for biting humans. These spiders typically reserve their bites for prey capture or defense. When humans are bitten, which is rare, the incident is typically accidental and the consequence is a mild, non-venomous reaction.

Long-winged kite spider is not inherently aggressive towards humans and bites are uncommon. Human encounters with long-winged kite spider may occur accidentally, such as when a person inadvertently disturbs their webs or habitats. Given that long-winged kite spider primarily uses its bite defensively or for prey capture, issues arise mostly from unintentional contact with humans rather than from seeking them out.

To minimize conflicts with long-winged kite spider, individuals can take steps to avoid disturbing their habitats. This includes being mindful of long-winged kite spider's webs and exercising caution when moving through areas where they may reside. Keeping living spaces clear of clutter can discourage long-winged kite spider from settling in those areas. Proper maintenance of outdoor spaces can help to manage their presence near human habitations.

If an individual accidentally comes into contact with long-winged kite spider, the primary goal is to calmly and carefully remove the spider or oneself from the situation without causing harm. For any physical symptoms, gentle cleaning of the area with soap and water is recommended. Additionally, using cold compresses can alleviate discomfort. It is important for individuals to avoid disturbing the affected area and allow it time to recover naturally, ensuring that further irritation or infection is prevented.