Columbia silk moth's potential to cause allergies in humans is mostly during its larval stage, where contact with its hair could trigger mild reactions in a small number of people. Common symptoms might include skin rashes or irritation. The risk is generally low, but individuals with sensitivity to insect hair should exercise caution.

Columbia silk moth resides in environments close to human habitation. During its larval stage, it possesses hair that can cause skin irritations upon contact. People may inadvertently touch or brush against columbia silk moth when outdoors, leading to mild allergic reactions, such as rashes, in sensitive individuals.

To prevent irritation caused by columbia silk moth, individuals should wear protective clothing such as long sleeves and pants when in areas where columbia silk moth is present. Ensuring living spaces are free from columbia silk moth through regular cleaning can also reduce contact. Educating vulnerable groups about columbia silk moth's habitat aids in avoiding unnecessary exposure.

Upon experiencing irritation from columbia silk moth, promptly wash the affected area with water to remove any microscopic hairs. Keeping living spaces well-ventilated and clean can help reduce the presence of columbia silk moth. Use cool compresses to soothe the skin. Biotechnological advances have enabled the use of harmless, non-chemical barriers to further minimize exposure. Recovery usually involves natural skin healing; thus, one should avoid scratching to prevent secondary infections.