Adults of modest masked bee possess a mild sting as a defense mechanism. The sting may deliver neurotoxins, which can cause temporary discomfort in humans. Although the toxicity is generally low, the sting can lead to immediate symptoms, such as localized pain and swelling. Long-term effects are unlikely, but in severe cases, complications could arise from multiple stings.

Modest masked bee has a defense mechanism that involves a mild toxin, which it delivers through a sting. This toxin is mostly active when modest masked bee is an adult. Among those affected include humans, who might experience swelling or pain at the sting site. Mammals could show similar mild reactions. Insects that get stung could be incapacitated or deterred, serving as a way for modest masked bee to protect itself from being preyed upon or bothered. The sting and its effects vary across animal species, from brief discomfort to more pronounced reactions, but it is generally not considered highly dangerous.