Furrow orbweaver can administer venom through its fangs, a feature particularly present in both its juvenile and adult stages. This species possesses a mild toxin with a dual function, impacting both vertebrates and invertebrates, albeit often yielding only minor discomfort in animals such as humans, dogs, cats, and rodents, and potentially proving more hazardous to smaller creatures like insects. Different species may experience varying reactions upon envenomation, largely depending on the dose of venom received and the size of the animal.

Furrow orbweaver does not typically display biting behavior towards humans. Bites are rare and primarily occur in self-defense when the spider feels threatened. Furrow orbweaver has fangs to inject venom but will do so mainly when provoked. Human encounters with furrow orbweaver bites are not common, often resulting in only minor localized symptoms due to their mild venom.

Furrow orbweaver seldom comes into contact with humans. However, troubles may arise on rare occasions when furrow orbweaver feels threatened and gets provoked. Since these spiders dwell in locations frequented by humans, inadvertent disturbances can lead to defensive biting. The mild venom can cause minor localized symptoms, but this is not a common occurrence.

To prevent unwelcome encounters with furrow orbweaver, avoid disturbing their webs or habitats. Implementing regular cleaning reduces the likelihood of furrow orbweaver residing in human spaces. Strategic placement of non-toxic deterrents, like essential oils known to repel arachnids, can also be effective in keeping furrow orbweaver at bay.

In the uncommon event of a furrow orbweaver bite, cleaning the area with soap and water helps to prevent infection. Applying a cool compress can reduce swelling and discomfort. It's crucial to ensure that the affected area is kept clean and monitored for any signs of complication. During recovery, refrain from scratching or disturbing the site to avoid further irritation or infection.