Lycosa erythrognatha poses a low risk to humans, with neurotoxins capable of eliciting mild symptoms via bites from their fangs during defense. Adults may cause localized pain, redness, and swelling. Severe complications are rare, but any neurotoxic impact is generally short-lived and not life-threatening.

Lycosa erythrognatha poses a risk primarily through biting, a defense mechanism employed when threatened. The venom, though typically mild, can cause discomfort in humans and a range of other mammals such as dogs, cats, and mice. Birds and different insects may also be affected by the adult lycosa erythrognatha's bite, with reactions varying depending upon the species. The toxin's impact ranges from negligible to moderate, seldom posing serious risks to these animals.

Lycosa erythrognatha typically does not bite humans; such incidents are rare. When they occur, it's usually in self-defense or due to accidental contact. Bites are mechanically facilitated by chelicerae, causing mild, non-lethal symptoms. Juvenile and adult behavior is similar in this defensive response.

Exposure to lycosa erythrognatha during its adult stage has the potential to evoke allergic reactions in a small subset of humans. These allergies range from mild to severe, typically manifesting after a bite. Allergic symptoms could include itching, redness, and swelling. Severity varies among individuals, with some experiencing more pronounced reactions. Caution is advised when encountering lycosa erythrognatha, especially for those with known sensitivities to arachnid venom.

Lycosa erythrognatha rarely interacts with humans, but when they do, it's often out of self-defense or accidental contact. Their chelicerae enable them to bite, which can inject neurotoxins, potentially causing mild symptoms like pain, redness, and swelling. People with allergies may also experience more severe reactions such as itching or pronounced swelling.

To prevent encounters with lycosa erythrognatha, maintain a clean and clutter-free environment. Seal cracks and crevices in walls, and install screens on windows to deter entry. Regularly dust and vacuum to disturb potential hiding places. Outdoors, keep foliage and woodpiles away from the perimeter of your home to reduce habitat attractions.

If an issue with lycosa erythrognatha arises, calmly and carefully remove yourself from the area to avoid further contact. Cleanse the area of contact with soap and water. Applying a cold compress can reduce swelling and alleviate discomfort. Monitor symptoms carefully; typically, they resolve on their own. During recovery, avoid scratching to prevent secondary infections and irritation. While symptoms are mild for most, seek advice if you have known sensitivities or symptoms persist.