Tuft-legged orbweaver primarily uses its venom defensively or to subdue prey, but generally, the toxicity is considered mild to other species. When tuft-legged orbweaver bites, humans may experience minor effects such as localized pain or itching. Smaller animals like insects might be more affected, potentially succumbing to the venom, which allows tuft-legged orbweaver to consume them. Pets such as dogs and cats, or small reptiles like lizards and amphibians such as frogs, could show discomfort when bitten. However, serious complications in larger animals are rare.

Tuft-legged orbweaver is not characteristic for biting humans. These arachnids typically reserve biting for defense and prey capture rather than interaction with humans. If a bite occurs, it's a rare defensive response, not habitual behavior. The immediate consequences of such bites are generally mild, given tuft-legged orbweaver's small size and relatively harmless venom to humans.

Tuft-legged orbweaver generally avoid contact with humans but may bite as a defensive measure if they feel threatened or if accidentally pressed against human skin. Since they share environments with us, notably gardens and homes, the potential for such rare, unintentional encounters can lead to the minor troubles usually associated with their bites.

To prevent accidental encounters with tuft-legged orbweaver, maintaining a clean home environment is critical. Regularly sweep and declutter areas like garages, basements, and corners where they may spin webs. Outdoors, wear gloves while gardening and be mindful when moving objects where tuft-legged orbweaver could hide.

For the rare instances that tuft-legged orbweaver may cause trouble, it's important to keep the affected area clean. Wash with soap and water and keep it sanitized. Applying a cold compress can reduce discomfort. Remember to move gently and avoid provoking tuft-legged orbweaver in its natural habitat to reduce further risk. During recovery, keeping the area clean and avoiding disturbance is advisable.