Basilica orbweaver uses its venom, typically discharged from fangs, to incapacitate potential threats and subdue prey, primarily during its adult stage. The venom contains a cocktail of chemicals causing mild reactions in humans and domestic animals such as dogs and cats, potentially leading to discomfort and localized symptoms. Insects, being a primary food source, are usually more severely affected, with the venom acting swiftly to immobilize them.

Basilica orbweaver typically does not exhibit aggressive biting behavior towards humans. Bites are extremely rare and would likely occur only in self-defense during an inadvertent encounter where the spider feels threatened. If a bite does happen, it is generally considered harmless with mild consequences, comparable to other adult spider defense mechanisms.

Basilica orbweavers generally avoid human contact and will only bite if they feel threatened, such as when inadvertently touched or pressed against. Their bites are typically a defensive response and are not a common occurrence. However, when bites do happen, the effects are usually mild, though they can cause discomfort due to the natural defense mechanisms of basilica orbweaver.

To prevent unwanted encounters with basilica orbweaver, keep living spaces clean and decluttered to reduce hiding spots. Use window screens to prevent basilica orbweaver from entering the home. When working in basilica orbweaver habitats, like gardens or storage areas, wear gloves and be mindful of their presence to avoid disturbing them.

If trouble with basilica orbweaver arises, calmly and carefully remove the basilica orbweaver without causing it stress. Clean the area gently with soap and water to prevent dirt from entering. Applying a cold compress can help soothe any discomfort. During recovery, avoid scratching or irritating the area to reduce the risk of secondary infection. Monitor for signs of excessive reaction and seek professional advice if necessary, keeping the area clean and avoiding any further disturbance to the site.