Leafcutting bee may possess a sting for defense that can inject venom into humans, potentially containing melittin. The toxin could cause localized pain and swelling. Immediate effects are mild, but multiple stings or hypersensitivity can lead to more serious complications.

Leafcutting bee are solitary bees that typically do not sting unless provoked. Only the females have the ability to sting as a defense mechanism if they feel threatened, notably when humans handle them or disturb their nests. Stinging incidents are rare; the bees prefer flight over fight. The sting may cause minor pain or allergic reactions in humans, but there is no significant impact on leafcutting bee post-stinging as their stinger is not barbed and they do not die after stinging.

The solitary nature of leafcutting bee means they rarely contact humans, but inadvertent proximity to their nesting sites could trigger a defensive response. Since only females can sting, and do so primarily when threatened or handled, the majority of humans will not be affected. Trouble arises from accidental disturbances or intentional handling of leafcutting bee.

To prevent issues with leafcutting bee, avoid areas where they are likely to nest, such as hollow twigs or holes in wood. Keep living environments tidy to discourage nesting. Wear protective clothing when working in areas where leafcutting bee may be present to minimize the chance of a defensive sting.

In the event of a sting by leafcutting bee, cleaning the area with soap and water is crucial to prevent infection. Use a cold compress to soothe any swelling or discomfort. Avoid scratching to reduce the risk of infection and monitor for signs of an allergic reaction. While recovering from any discomfort caused by leafcutting bee, it's important to rest and allow the body to heal. Inform others of the incident for increased monitoring and assistance.