Sand bee can cause mild poisoning in a range of animals through its sting during its adult stage. As a means of securing prey, sand bee utilizes its venom to subdue or deter potential threats. Humans and domestic animals such as dogs may experience local discomfort if stung, while smaller animals like rats might suffer more due to their size. Butterflies and similar creatures can also be affected, deterring them from predation or interaction with N. The severity of the reaction to N's toxin varies widely among different species, generally resulting in mild symptoms.

Sand bee is not known for regularly stinging humans. These solitary wasps typically use their sting to paralyze prey for their larvae rather than for defense. Human incidents are rare and mainly occur when provoked or accidentally disturbed. When stinging occurs, it is mainly because of the wasp's effort to escape or protect itself.

Troubles to humans from sand bee are uncommon, as these solitary insects usually reserve their sting for immobilizing prey. However, human encounters may occasionally result in a sting, often due to inadvertent provocation or disturbances, such as stepping on or handling the insect without realizing it. The wasp's defensive behavior is typically a last resort to escape or safeguard itself.

To prevent accidental stings by sand bee, one should take care not to disturb areas where they might be present. Keeping outdoor spaces clear of debris where sand bee may nest and remaining vigilant while in nature can reduce encounters. Wearing protective clothing and avoiding sudden movements near these insects can also help prevent stings.

For relief from sand bee sting symptoms, cleaning the affected area with soap and water helps reduce the risk of infection. Applying a cold compress can ease pain and swelling. Distracting oneself with calm activities or using a fan for cool air circulation may also alleviate discomfort. If symptoms persist or worsen, seeking professional advice without delay is suggested. During recovery, it is prudent to rest and avoid disturbing any other potential sand bee habitats.