The spotted orbweavers has a defense mechanism for dissuading potential predators or threats, which involves a mild sting. When spotted orbweavers feels threatened, it uses its sting to inject venom. This can cause discomfort and localized reactions among humans and various animals, including domestic pets and certain wild mammals. Smaller creatures may experience more acute effects due to the potency of the venom in relation to their body size. However, for most larger animals, the experience is uncomfortable rather than life-threatening.

Spotted orbweavers is not typically known for biting humans. Incidents of spotted orbweavers biting humans are rare, often occurring defensively if provoked or threatened. Bites may result from accidental contact, with consequences generally being mild due to the spider's non-aggressive nature towards humans.

Spotted orbweavers occasionally may cause distress due to accidental encounters with humans. These instances are typically defensive and out of protection rather than aggression. Since spotted orbweavers share habitats with people, especially in dark, undisturbed areas, contact may happen inadvertently, leading to bites that although rare, can cause discomfort.

To prevent run-ins with spotted orbweavers, regular cleaning and decluttering can reduce hiding spots in homes. Utilizing insect-repelling plants or essential oils, and installing fine mesh screens on windows can deter these creatures from inhabiting living spaces, thereby minimizing any potential for bites.

In the event of an undesired interaction with spotted orbweavers, it's advisable to gently remove the animal using non-hazardous methods. Afterward, cleaning the affected area with soap and water is recommended. Maintaining a peaceful environment can aid in recuperation. Avoiding disturbance of their habitat can prevent future occurrences and allow for coexistence.