Arabesque orbweaver typically harms others through a bite, delivering venom via its fangs. While the toxicity is mild for humans and larger animals like dogs, they may experience discomfort and minor symptoms. Smaller creatures, such as rodents and insects, might have more severe reactions to the venom due to their size and physiological differences. Both young and mature arabesque orbweaver are capable of envenomation, posing a risk from early stages of development through adulthood.

Arabesque orbweaver typically does not bite humans and such behavior is not characteristic of this species. When encountered, they likely employ biting as an uncommon defense mechanism, with consequences being mild due to their relatively harmless venom to humans.

The reason why arabesque orbweaver can cause troubles to humans is not rooted in aggression but in their defensive behavior when feeling threatened. Humans may inadvertently come into close contact with arabesque orbweaver, particularly if they disturb arabesque orbweaver's web or habitat, prompting a defensive bite. Nonetheless, such occurrences are rare and typically result in minimal harm due to the species' non-potent venom to humans.

To prevent problems with arabesque orbweaver, it's important to be cautious in areas where they may live or build webs. Use environmental modifications such as regular cleaning of corners and less-frequented areas in homes. Seal cracks and crevices to deter arabesque orbweaver from entering. Outdoor lighting designs that do not attract flying insects can reduce the likelihood of arabesque orbweaver setting up nearby webs.

If an encounter with arabesque orbweaver leads to physical symptoms, gently cleaning the affected area with soap and water can help. Applying a cool compress can reduce discomfort. Assuring that the area is kept clean and not rubbed or scratched will help aid in the natural healing process. Individuals should also ensure rest and practice good hygiene to support recovery. Additionally, should troubles persist, they may consult a professional for further non-medical advice.