Pointillist neoscona has a mild venom that it administers via its fangs when biting. Typically, this species' venom causes minor discomfort in larger animals like humans, dogs, and cats, which may include localized pain or swelling. Smaller creatures may experience more severe reactions due to their size and differences in physiology. The toxin is primarily used by pointillist neoscona for defense and hunting. Since the intensity is low, reported cases of poisoning often result from accidental encounters, and serious complications are rare.

Pointillist neoscona does not typically engage in biting humans. Instances of such behavior are rare and would occur mainly in self-defense. If bites do occur, they are likely from mature individuals employing their fangs, resulting in mild consequences for the human, indicative of the species' non-aggressive nature towards humans.

Pointillist neoscona rarely come into direct conflict with humans as biting is usually a defensive response rather than an aggressive one. When humans invade their space, perhaps while cleaning or reaching into rarely disturbed areas, they act out of self-preservation. The interaction is incidental and not sought after by pointillist neoscona.

To prevent unwanted encounters with pointillist neoscona, maintain regular cleaning schedules to avoid the accumulation of webs in living spaces. Use natural deterrents such as chestnut, lemon or peppermint oil essence around the home, as these are known to repel pointillist neoscona. Ensure that window screens are intact to prevent pointillist neoscona from entering.

Should an encounter with pointillist neoscona occur, it is important to stay calm. Gently remove the pointillist neoscona or safely guide it outside. To soothe any minor irritation from an accidental bite, clean the area with soap and water and apply a cool compress to reduce discomfort or swelling. Recovery is typically swift, but during this time, avoid disturbing other potential pointillist neoscona habitats to prevent repeated incidents.