Neoscona scylloides can deliver venom through a sting, causing a range of reactions from mild irritation to severe allergic responses. In humans, the sting often results in pain and swelling, while dogs might experience discomfort and hypersensitivity. Birds and other small animals could exhibit distress, and some may become ill. Among different insects, the sting could be incapacitating or lethal, depending on the species and circumstances. The adult stage of neoscona scylloides is typically when it poses a risk, with toxic effects varying between animal groups.

Neoscona scylloides typically does not exhibit biting behavior towards humans. Bites are rare and generally only occur in self-defense when the spider is directly threatened. The method involves a quick, mild bite, mainly as a last resort defensive mechanism. Human bites, when they happen, have minor consequences, such as localized pain or irritation.

The species neoscona scylloides, rarely bites humans, and such incidences usually arise when it is threatened or accidentally comes into contact with people. The bite, a defensive act rather than one of aggression, could result in temporary discomfort mainly due to the creature's instinct to protect itself when pressed or crushed against human skin.

To prevent encounters with neoscona scylloides, maintain cleanliness and reduce clutter in homes and surroundings where they may take refuge. Use window screens to prevent entry and employ regular pest control measures. Limit outdoor lighting that attracts insects, which are food sources for neoscona scylloides, thereby reducing their incentive to enter human dwellings.

After an inadvertent interaction with neoscona scylloides leading to a bite, keep the area clean and apply a cold compress to alleviate any discomfort. It is essential to stay calm and avoid scratching the affected region to prevent secondary infection. During recovery, ensure good personal hygiene and maintain a clutter-free environment to deter further incidents. Monitor the site for changes and seek professional advice if needed without delay.