Novaranea queribunda is known for its ability to poison animals through its bite, delivering venom via fangs. While the toxicity of novaranea queribunda is generally considered mild, it may still cause discomfort and reactions among various animals. Humans, as well as household pets like dogs and cats, may experience localized pain or swelling. Smaller mammals might show more intense reactions due to their size, whereas insects and similar critters could succumb to the venom more readily. The adult stage of novaranea queribunda is specifically noted for being toxic.

Novaranea queribunda does not typically exhibit biting behavior towards humans. When such instances occur, they are predominantly defensive, particularly if an adult novaranea queribunda feels threatened. Methods of biting are similar to other arachnids, but consequences of bites to humans are generally mild, with symptoms rarely persisting beyond a minor irritation.

Novaranea queribunda rarely exhibit aggressive behavior towards humans and typically only bite when feeling threatened. Encounters may occur if a novaranea queribunda perceives a human as a predator or if inadvertently provoked. Due to humans encroaching upon their natural habitats, the likelihood of such defensive bites can increase, although the symptoms are often mild and not of serious consequence.

To minimize interactions with novaranea queribunda, one can adopt simple habitat modifications. Keeping living spaces clean and free of clutter can deter novaranea queribunda from residing in human habitats. Seal cracks and crevices in walls to prevent entry. Regularly removing any webs found around the home can also discourage novaranea queribunda from settling in human-occupied areas.

If a novaranea queribunda bite occurs, the affected area should be washed with soap and water to prevent infection. Applying a cold compress can reduce discomfort and swelling. To minimize the adverse effects, it is advisable to avoid disturbing the bite site further. During recovery, keep the area clean and monitor for signs of secondary infection, seeking professional advice if symptoms escalate.