Wall spider possesses a toxic defense mechanism that primarily acts through biting with its fangs. The venom is of mild intensity and serves as a means to subdue prey. Adults are typically the toxic stage of wall spider. Exposure to this toxin can cause discomfort among various animals, including humans, dogs, cats, and birds. As a defense strategy or a method to immobilize prey, the effect on these animals can range from mild irritation to allergic reactions, although it is not generally considered life-threatening.

Wall spider rarely bites humans. Bites occur typically in defense when the spider feels threatened. Despite their ability to bite, wall spider mostly avoids humans and consequences of bites are generally mild, without significant long-term health issues.

Wall spider seldom bites humans, only doing so in a defensive stance when feeling threatened. Their preference to steer clear of human interaction minimizes bites, yet such incidents may result from accidental encounters. The mildness of bites means they seldom lead to severe health issues, although they can cause temporary discomfort.

To reduce encounters with wall spider, maintaining a clean environment can discourage their presence. Sealing cracks in walls and using window screens can prevent them from entering homes. Regularly dusting and vacuuming to remove any webs may also discourage wall spider from settling in living spaces, further reducing the likelihood of interactions.

If a person does experience discomfort from a wall spider interaction, thoroughly cleaning the area with soap and water is advisable. Using a cold compress can alleviate symptoms by reducing any inflammation or irritation. Additionally, ensuring the area remains clean can prevent infection. Encouraging the person to rest and maintain a clean environment can support a swift recovery, and being gentle and cautious with the affected area is paramount.