Golden jumping spider can cause mild discomfort through its venom, typically when it feels threatened or during predatory activities. The adults use their fangs to inject the toxin into their prey or offenders. While the effects on humans and dogs usually involve minor symptoms such as localized pain or swelling, small mammals may experience more pronounced reactions. Insects, which might be its prey, can be immobilized or killed, illustrating the venom's effectiveness in golden jumping spider's hunting strategy.

Golden jumping spider is not generally known to bite humans. When golden jumping spider does bite, it is typically a defensive action rather than aggressive behavior. Such instances are rare and often result from direct provocation or when the spider feels threatened. The bites are seldom serious and might only cause minor, localized discomfort.

The trouble caused by golden jumping spider to humans arises mainly when they feel threatened or provoked, leading to a rare but possible defensive bite. Golden jumping spider typically does not seek out human interaction and prefers to avoid such encounters. The rare bites can cause minor discomfort due to golden jumping spider's natural instinct to defend itself when accidentally disturbed by humans.

To prevent unwanted encounters with golden jumping spider, keep living areas well-maintained and free of clutter where they might seek refuge. Regularly inspect and seal any cracks or openings around windows, doors, and walls. Limiting their habitat helps discourage golden jumping spider from entering human dwellings and reduces the chance of defensive bites.

If trouble occurs due to a golden jumping spider bite, maintain a clean environment to calm the site as golden jumping spider bites are seldom serious. Wash the affected area with soap and water and apply a cold compress to minimize discomfort. Avoid disturbing the area further, as golden jumping spider only bite defensively. During recovery, refrain from interacting with golden jumping spider habitats and immediately address potential attractions or shelters for golden jumping spider. Regular home maintenance, reducing hiding spots, can minimize future adverse consequences.