Putnam's jumping spider typically uses its venom to subdue prey and as a means of defense. It delivers venom through bites with its fangs. Though the venom is considered mild, it can cause discomfort and localized reactions in humans and domestic animals such as dogs and cats. Smaller animals, like birds and rodents, might experience more severe symptoms due to their size and differences in physiology.

Putnam's jumping spider typically refrains from biting humans. Bites are accidental and defensive, not habitual. When it occurs, it's due to perceived threats and the need for self-protection. The bite employs their fangs, inflicting a mild and usually harmless reaction. Habitual human biting is not characteristic of putnam's jumping spider.

The discomfort caused by putnam's jumping spider is largely due to their self-defense mechanism against perceived threats. When putnam's jumping spider feel threatened or are mishandled by humans, they may bite in defense. These encounters are typically accidental, as putnam's jumping spider don't naturally seek out human contact. However, their presence in human-inhabited areas increases the likelihood of such defensive reactions.

To prevent negative interactions with putnam's jumping spider, it is essential to maintain a clean and clutter-free environment, as these conditions deter putnam's jumping spider from taking residence near humans. Sealing cracks and gaps in homes can prevent them from entering indoor spaces. Additionally, being cautious when moving objects where putnam's jumping spider may reside can minimize the risk of accidental encounters.

Following an undesired interaction with putnam's jumping spider, keeping the area clean and avoiding aggravation is important. Frequent cleaning can deter further putnam's jumping spider visits. In case of a defensive reaction from putnam's jumping spider, washing the affected area with soap and water is advisable. Using cold compresses can help to relieve any discomfort. During recovery, refrain from disturbing the site of the interaction to prevent secondary issues. It is also beneficial to ensure putnam's jumping spider habitats are not conducive within personal spaces to avoid repeat incidents.