Phidippus texanus possesses a mild venom which is used primarily for predation and defense. When it bites, the venom is delivered through fangs and can cause discomfort in animals such as humans and various mammals. Typically, insects and other small creatures may experience more severe reactions due to their smaller body sizes. However, the toxicity level varies and often doesn't lead to serious harm in larger animals. The adult stage of phidippus texanus is when it exhibits the toxicity necessary to fend off attackers or subdue prey.

Phidippus texanus rarely bites humans; such incidents occur mainly in defense. When threatened, phidippus texanus employs its fangs to deliver a bite, resulting in mild and typically harmless symptoms. Human encounters with phidippus texanus that lead to biting are exceptional, as this species generally avoids contact.

Phidippus texanus, as a member of the Salticidae family, are generally not aggressive towards humans and bites are rare, mostly occurring out of defense if they feel threatened. In their natural habitat, they are predacious and may wander into human dwellings in search of prey, inadvertently coming into close contact with humans.

To prevent unpleasant encounters with phidippus texanus, it's important to maintain a clean environment, reducing the presence of their prey. Use of fine mesh screens on windows and doors can inhibit their entrance into homes. Regularly inspecting and clearing spaces where they may hide will discourage them from settling.

In the rare event that phidippus texanus causes distress, promptly washing the affected area with soap and water will help. Applying a cold compress can alleviate discomfort. Ensuring the maintainance of a clean and calm environment will aid in recovery. It is also important to avoid disturbing phidippus texanus habitats to minimize further interactions.