Giant desert centipede possesses venomous fangs, or forcipules, which inject neurotoxins during predation and defense. While a bite to humans usually results in mild symptoms like pain and swelling, it can potentially lead to more severe reactions, including tachycardia and necrosis. Juvenile and adult giant desert centipede share these toxic traits, and while bites are uncommon, they pose a risk of toxic impact on human health.

Giant desert centipede typically poisons other animals through its sting, mainly as a defense mechanism or when securing prey. The mild toxicity of the venom affects humans, mammals, and arthropods differently. Humans may experience mild discomfort and localized pain. Mammals, such as small domestic animals, might show more pronounced reactions to the venom, depending on their size and the amount of venom received. Arthropods, being smaller and often prey, can be more seriously affected or paralyzed by the sting. The venom's effects are most potent during the organism's adult stage.

Giant desert centipede bites humans primarily in self-defense. They use forcipules—pincer-like appendages—to inject venom. Bites occur when giant desert centipede feels threatened or is inadvertently disturbed, often resulting in sharp pain and swelling, but generally not life-threatening for humans.

The predatory giant desert centipede uses its powerful jaws to capture and subdue prey. It employs venom to incapacitate or kill for nourishment, while also defending itself from potential threats. Its hunt is nocturnal, relying on stealth and speed to overpower various terrestrial targets.

Giant desert centipede, a member of the Scolopendridae family, often comes into conflict with humans due to their nocturnal and predatory nature, as well as their preference for dwelling in dark, moist environments that can overlap with human habitats. When threatened or disturbed, they may bite, releasing neurotoxins that can cause pain and swelling among other symptoms.

To prevent encounters with giant desert centipede, ensure that homes are well-sealed, and reduce moisture by repairing leaks. Keep clutter to a minimum and inspect dark areas regularly. Use physical barriers, like screens or door sweeps, and consider natural repellents or deterrents that discourage giant desert centipede from entering living spaces.

After an encounter with giant desert centipede resulting in a bite, clean the affected area with soap and water to minimize the risk of infection. Applying a cold compress can help reduce pain and swelling. It's important to rest and avoid strenuous activity during recovery. If symptoms worsen or if you have concerns, seek professional assessment while continuing to maintain a clean and calm environment for healing.