Tube web spider is known to possess venom that aids in subduing its prey. While this venom contains neurotoxins that can immobilize small insects, it typically has a mild effect on humans. A bite may result in localized pain, redness, and swelling. Serious complications are rare, but discomfort can persist for a few days. The species' fangs deliver venom when they feel threatened, yet the risk to humans is generally low.

Tube web spider possesses a venom with mild toxicity that is secreted through its fangs. While its toxicity is typically low-grade, bites can cause discomfort and localized reactions in humans, pets like cats and dogs, as well as small mammals such as rodents. Fortunately, the potential for severe consequences is limited due to the mild nature of the venom, primarily resulting in temporary pain or irritation at the site of the bite. The venom is typically deployed defensively when tube web spider is provoked, and its effects are most pronounced during the adult stage of the organism.

Tube web spider, while not commonly biting humans, may do so defensively or when provoked. Their bites, typically mild with minor symptoms, are a method of self-preservation. Humans are not prey for tube web spider, so bites are rare and usually occur only upon accidental contact.

Tube web spider may occasionally cause discomfort to humans due to its defensive nature when threatened. They generally avoid human contact but may bite if provoked or accidentally disturbed, such as when a person puts on a shoe where tube web spider is hiding. The bite can cause localized pain and swelling, although it is not typically dangerous and incidents are low.

To prevent unpleasant encounters with tube web spider, it is advisable to keep living environments clean, reducing clutter where tube web spider may hide. Regularly checking and shaking out clothing, shoes, and bedding before use can also deter unwelcome interactions. Sealing cracks and crevices in the home helps to minimize their entry points.

In the rare event of experiencing symptoms following a tube web spider bite, cleaning the area with soap and water can prevent infection. An ice pack may be applied to reduce swelling and discomfort. It's important to avoid scratching the bite to prevent secondary infections. Rest and keeping the affected area elevated can help in recovery. During the healing period, monitor the bite for signs of increased redness, swelling, or pain, and seek professional advice if the symptoms persist or worsen.