Large brown vagrant spider is mildly toxic, secreting venom through its fangs primarily as a defensive mechanism and to immobilize prey. When it bites, humans and mammals, such as dogs, may experience localized discomfort and minor reactions, while smaller animals like rats might become incapacitated. Various insects, upon envenomation, could suffer paralysis or death due to their smaller body mass and different physiology. Both juvenile and adult stages of large brown vagrant spider possess the ability to envenomate, posing a risk to a wide range of animals.

Instances of large brown vagrant spider biting humans are not characteristic of this species. They typically do not engage in aggressive behavior towards humans, and such cases are uncommon. When they do occur, it's usually a defensive response rather than a predatory strategy, and the consequences of the bite are generally mild.

Large brown vagrant spider is not typically aggressive towards humans; however, they can bite in self-defense if they feel threatened. Since they live in proximity to human habitats, unintended encounters can occur. These instances are not common and usually result in mild consequences, though they can be distressing if unexpected.

To prevent unintentional encounters with large brown vagrant spider, maintain a clean living environment. Seal entry points like cracks or gaps in walls and foundations. Clear away clutter where large brown vagrant spider may hide. Regularly inspect hidden areas, and use window screens to discourage indoor incursion by any large brown vagrant spider.

If bitten by a large brown vagrant spider, keep the affected area clean and avoid scratching to reduce the risk of infection. Calm measures such as gently washing the area with soap and water followed by applying a cool compress can help soothe any discomfort. During recovery, refrain from disturbing the bite site and keep it clean. Remember, most bites from large brown vagrant spider result in mild symptoms, and significant consequences are rare. Rest and ensuring a clean living environment are key to a swift recovery.