The species raft spider typically employs its venom in self-defense and to subdue prey. When this species bites, it can deliver venom through its fangs, although the effects are generally mild. While humans might experience minor discomfort or localized reactions, smaller animals such as rodents could exhibit stronger symptoms. Insects, being more acutely affected by the venom, may be paralyzed or killed, enabling raft spider to feed. Juveniles and adults alike are capable of envenomation, with their toxicity not varying significantly with age.

Raft spider is not known to commonly bite humans. When it does, it's primarily in self-defense. Biting typically occurs if they feel threatened or if they are mishandled, considering their defensive nature in adult stages. Bites can result in mild discomfort but are not generally harmful to humans.

Raft spider's interaction with humans usually occurs when their habitat overlaps with human dwellings or during unexpected encounters. Due to their defensive nature, raft spider may bite if they feel threatened or are accidentally disturbed, for instance, when a human inadvertently comes into contact with them.

To prevent encounters with raft spider, maintain a clean environment by removing clutter where they may nest. Seal cracks and crevices in walls and foundations, and use screens on windows and doors. Regularly check and clear seldom-used areas of your home such as garages, basements, and storage rooms.

If bitten by raft spider, calmly and gently remove the raft spider without squeezing it. Clean the area with soap and water to prevent secondary infection. Applying a cold compress can reduce swelling. It's important to avoid scratching the bite to allow it to heal properly. During recovery, staying mindful of keeping the affected area clean is crucial.