The venom of ladybird spider is of a mild intensity and is used to subdue prey as well as for defense. It can affect both humans and animals, resulting in discomfort and varying reactions depending on the individual's sensitivity, size, and overall health. When bitten, humans might experience localized pain and mild systemic symptoms, whereas smaller animals such as dogs or cats may show more pronounced symptoms due to their size. Larger animals typically experience less severe effects. Juveniles and adults of ladybird spider both possess the capability to envenomate through their fangs.

Ladybird spider typically exhibits biting behavior only as a defense mechanism. These bites are rare and often occur when the spider feels threatened or trapped. Adult ladybird spider may bite in self-defense, but the impact is typically mild and not serious for humans.

Ladybird spider generally avoid humans and bite only in self-defense, usually when feeling threatened or trapped. Instances of bites are relatively rare. When bites do occur, they typically result in minor symptoms which are not severe for humans.

To prevent unwanted encounters with ladybird spider, keep living spaces clean and reduce clutter that can provide hiding spots. Use window screens and door sweeps to inhibit indoor entry. Avoid reaching into dark or unseen areas without checking them first.

In the event of a bite, keeping the affected area clean and avoiding scratching can help to reduce any discomfort. Employing cold compresses can alleviate symptoms. It's important to keep the bite area sanitized and monitor the site for any signs of complications, while refraining from any strenuous activities that may aggravate the area. Consulting a healthcare professional is advised if symptoms persist or worsen.