Yellow-and-black flat millipede possesses a natural defense mechanism that can release neurotoxins harmful to humans if touched or ingested. Skin penetration is not a typical concern as yellow-and-black flat millipede does not inject toxins but may produce mild skin irritation on contact. Severity is generally low, with symptoms like itching or burning sensations. Ingestion, though unlikely, could lead to more significant gastrointestinal discomfort but is rarely life-threatening. Long-term effects are minimal; however, repeated exposure should be avoided to prevent potential cumulative discomfort.

Yellow-and-black flat millipede possesses a mild venom that it can deliver through a sting. Adult yellow-and-black flat millipede use their venom primarily for defense against predators. When humans or other mammals, such as dogs, happen to disturb yellow-and-black flat millipede, they may experience discomfort or a mild allergic reaction upon being stung. Arthropods that fall victim to yellow-and-black flat millipede's sting might suffer more severe consequences due to their smaller size and different physiology, which can make them more vulnerable to the toxins.

Yellow-and-black flat millipede's tendency to secrete neurotoxins as a defensive measure when threatened or disturbed can cause discomfort for humans. As yellow-and-black flat millipede does not actively attack, problems typically arise from accidental handling or unknowing contact. Their secretions may result in mild skin irritation including itching or burning sensations, primarily due to humans' unwitting interaction with these creatures in their natural habitats.

Preventing issues with yellow-and-black flat millipede involves minimizing direct contact by wearing gloves and long sleeves when handling organic material where yellow-and-black flat millipede may reside. Educating individuals about yellow-and-black flat millipede and their behavior can also reduce accidental exposure. Habitual checking of clothing and outdoor gear before and after use is advisable to avoid inadvertently coming into contact with these creatures.

After inadvertent contact resulting in irritation, cleansing the affected area with soap and water is recommended to remove any residues. Using cold compresses can soothe mild skin discomfort. Remain calm and avoid scratching to prevent secondary infections. It is essential for individuals to be aware of their symptoms and, although severe reactions are rare, they should monitor their condition and seek professional assistance if symptoms persist or worsen during recovery.